By Alan S. Curry
This number of 9 essays by way of top professionals considers the appliance of the main lately constructed analytical options and gear to specific poisons and medicine. It describes using HPLC, fluorescence research, and radioimmunoassays in toxicology and indicates tools particular to forensic drugs.
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Additional resources for Analytical Methods in Human Toxicology: Part 2
The resultant immunogens are normally injected into animals as an aqueous solution mixed with an oil-containing adjuvant to form a stable emulsion, since this increases the probability of evoking a good immune response . The choice of animals for raising antibodies is dependent on a number of factors. Antibody titres to small molecular weight hap tens seldom reach really high levels, therefore antibodies for immunoassay are, in principle , best pro duced in large animals such as goats and sheep from which large quantities of antiserum can be obtained.
1974). , and O'Connor, M. ). Drugs and the Poisoned Patient - The Role of the Laboratory, Ciba Foundation Symposium No. 26. Elsevier, Amsterdam and Oxford, 83-100. Mrochek , J. , Christe, W. , and Dinsmore, S. R. (1974). cu« Chem. 20, 1086-96. Nation, R. , Peng, G. , and Chiou , W. L. (1978). J. Pharm. Sci. 67 , 805-8. Osselton, M. D. (1981). In Reid, E. ). Trace Organic Sample Handling, Vol. 10, Methodological Surveys in Biochemistry. Ellis Horwood, Chichester, 10 1-10. Paanakker, J . , Thio, J.
Chemical Derivatization in Liquid Chromatography , Elsevier, Amsterdam. McDonald , R. S. (1982). Analyt. Chem. 54, 1250 . Martin, A. J . , and Synge , R. L. M. (1941) . Biochem. J. 35, 1358-68. Matin, S. , Karam , J. , and Forsham, P. H. (1975). Analyt. Chem. 47,545-8. Meffin, P. , and Miners, J . O. (1980). In Bridges, J. , and Chasseaud, L. F . ). Progress in Drug Metabolism, Vol. 4, Wiley, Chichester, 261-307. Miles, L. E. , and Hales, C. N. (1968). Nature 219,186 . Moffat, A. C. (1974). , and O'Connor, M.
Analytical Methods in Human Toxicology: Part 2 by Alan S. Curry