By T. Scott Stroup, Jeffrey A. Lieberman
Antipsychotic medicines are a key remedy for schizophrenia and revenues of antipsychotic medicinal drugs technique $20 billion consistent with yr, with fierce advertising and marketing among the makers of the medicine. The U.S. nationwide Institute of psychological health and wellbeing backed the medical Antipsychotic Trials of Intervention Effectiveness (CATIE) undertaking to supply self reliant information regarding the comparative effectiveness of medicines. CATIE was once the most important, longest and such a lot complete examine of schizophrenia thus far. performed less than rigorous double-blind stipulations, Antipsychotic Trials in Schizophrenia provides the definitive archival result of this landmark examine. The center of the ebook includes chapters thinking about particular results that set the CATIE findings in a much wider context. additionally integrated are chapters at the layout, statistical analyses and implications for researchers, clinicians and coverage makers. Psychiatrists, psychiatric researchers, psychological health and wellbeing coverage makers and people operating in pharmaceutical businesses will all locate this to be crucial examining.
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Extra resources for Antipsychotic Trials in Schizophrenia: The CATIE Project
The CATIE executive committee took the responsibility to ensure that each statistical analysis reported by the CATIE team was focused on one domain and followed a multiple comparison strategy that addressed the multiple outcomes, multiple phases, and multiple treatment comparisons. The analysis plan for the primary effectiveness outcome was finalized prior to completion of the study. Primary outcome: time to all-cause treatment discontinuation The primary CATIE outcome domain was specified as overall treatment effectiveness.
A random subject effect and a spatial power covariance structure were used to adjust standard errors for the correlation of observations from the same individual. Some analyses used an autoregressive or an unstructured covariance matrix. Spatial power is an extension of the autoregressive structure that accounts for unequally spaced intervals. If the treatment-by-time interaction was not significant, it was removed from the model, in order to obtain treatment group differences averaged across all time points.
5. Stroup TS and Geddes JR. Randomized controlled trials for schizophrenia: Study designs targeted to distinct goals. Schizophrenia Bulletin 2008;34:266–74. 2. Hotopf M, Churchill R and Lewis G. Pragmatic randomised controlled trials in psychiatry. British Journal of Psychiatry 1999;175:217–23. 6. Kemp R, Hayward P, Applewhaite G, et al. Compliance therapy in psychotic patients: Randomised controlled trial. British Medical Journal 1996;312:345–9. 3. March JS, Silva SG, Compton S, et al. The case for practical clinical trials in psychiatry.
Antipsychotic Trials in Schizophrenia: The CATIE Project by T. Scott Stroup, Jeffrey A. Lieberman