By Elke Hahn?Deinstrop(auth.)
Thin-layer chromatography (TLC) is a strong, quick and cheap analytical approach. It has confirmed its usefulness in pharmaceutical, nutrients and environmental research. This new version of the sensible TLC consultant includes a thoroughly revised bankruptcy on documentation, now together with using electronic cameras. chosen new sorbents and tools also are introduced.
Why has the previous version been profitable? All steps of the analytical process are essentially defined, beginning with the alternative of an acceptable TLC method and finishing with facts assessment and documentation. certain emphasis is wear the correct collection of fabrics for TLC. houses and services of assorted fabrics and the TLC gear are defined, protecting e. g. precoated layers, solvents and constructing chambers, together with details on providers. Many functional tricks for difficulty capturing are given. All this can be illustrated with various colored figures.
the way to use TLC in compliance with GLP/GMP laws is defined intimately, together with the mandatory documentation. hence the reader can comfortably assemble his personal ordinary working procedures.Content:
Chapter 1 creation (pages 1–13):
Chapter 2 Precoated Layers (pages 15–33):
Chapter three earlier than the TLC improvement approach (pages 35–68):
Chapter four Solvent structures, constructing Chambers and improvement (pages 69–112):
Chapter five review with out Derivatization (pages 113–123):
Chapter 6 Derivatization (pages 125–151):
Chapter 7 assessment After Derivatization (pages 153–180):
Chapter eight Documentation (pages 181–201):
Chapter nine GMP/GLP?Conforming Operations in TLC (pages 203–239):
Chapter 10 results of pressure (pages 241–245):
Chapter eleven targeted tools in TLC (pages 247–252):
Chapter 12 Appendix (pages 253–270):
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Extra resources for Applied Thin-Layer Chromatography: Best Practice and Avoidance of Mistakes, Second Edition
G of a new batch for testing Photograph Section King of the Lions Destruction of the Earth Long Legs Fountain 307 1 Introduction Thin-layer chromatography (TLC) is a very old method of analysis that has been well proven in practice. For more than thirty years, it has occupied a prominent position, especially in qualitative investigations. With the development of modern precoated layers and the introduction of partially or completely automated equipment for the various stages of operation of TLC, not only are highly accurate quantitative determinations now possible, but also the requirement that the work should comply with the GMP/GLP guidelines can be fulfilled.
Unfortunately, at least 95 % of the experiments were performed with TLC plates prepared in-house, so that full evaluation of these would be problematical. The English edition is in preparation. 2 Journals No journal in the German language exists which deals exclusively with TLC. Many authors are of the opinion that only articles in English can provide the necessary wide distribution and thus attract enough attention to their research results. 1 German Language Journals Containing Articles on TLC (Selection) Chrom View, Eigenverlag Merck KGaA, Darmstadt Deutsche Apotheker Zeitung, (DAZ), Deutscher Apotheker Verlag, 70191 Stuttgart Die pharmazeutische Industrie (pharmind), Editio Cantor Verlag, 88322 Aulendorf Die Pharmazie, up to 1991 VEB Volk und Gesundheit, Berlin, from 1991 Govi-Verlag, 65760 Eschborn/Taunus GIT Fachzeitschrift für das Laboratorium und GIT SPEZIAL Chromatographie, GIT-Verlag, Darmstadt LABO, Kennziffer-Fachzeitschrift für Labortechnik, Verlag Hoppenstedt GmbH, Darmstadt Laborpraxis, Vogel-Verlag, Würzburg Naturwissenschaften im Unterricht Chemie (NiU-Chemie), E.
It was first described as a stand-alone analytical method in the European Pharmacopoeia of 1974 (Ph. Eur. 1), where TLC was specified for the identification of 23 drugs. One year later, in the second issue of the DAB7, TLC identification was specified for a further 18 drugs. TLC is now established in almost all the pharmacopoeias of the world, although only for identification and purity testing. The improvements achieved over 30 years in sorbents, solvent systems and detection reagents and the use of partially and fully automated equipment for sample application, development and densitometric determinations on substances are beginning to appear in the monographs of all pharmacopoeias, although rather slowly.
Applied Thin-Layer Chromatography: Best Practice and Avoidance of Mistakes, Second Edition by Elke Hahn?Deinstrop(auth.)