By Jose Jalife, Mario Delmar, Justus Anumonwo, Omer Berenfeld, Jerome Kalifa(auth.)
This publication interprets basic wisdom in simple cardiac electrophysiology from the bench to the bedside. Revised and up to date for its moment variation, the textual content deals new insurance of the molecular mechanisms of ion channel habit and its legislation, complicated arrhythmias, and the broadening roles of units and ablation. transparent, easy reasons are illustrated by way of considerable diagrams to make the fabric available to the non-specialist.Content:
Chapter 1 Bioelectricity (pages 7–42):
Chapter 2 Ion Channels (pages 43–71):
Chapter three Ion Channel law (pages 72–91):
Chapter four Impulse Initiation and Propagation in Cardiac Muscle (pages 92–120):
Chapter five expense Dependency of Discontinuous Propagation (pages 121–151):
Chapter 6 simple Mechanisms of Cardiac Arrhythmias (pages 152–190):
Chapter 7 Rotors, Spirals, and Scroll Waves within the middle (pages 191–223):
Chapter eight Rotors and the Mechanisms of Atrial traumatic inflammation (pages 224–253):
Chapter nine Molecular Mechanisms of Ventricular traumatic inflammation (pages 254–275):
Chapter 10 Inheritable Arrhythmogenic illnesses (pages 276–315):
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Extra info for Basic Cardiac Electrophysiology for the Clinician, Second Edition
In the chapters that follow, we make repeated use of these concepts when discussing the properties of various membrane currents and the propagation of currents along tissues in the normal as well as the diseased heart. CHAPTER 2 2 Ion Channels Cardiac electrical excitation requires charges, primarily Na, K, Ca, and Cl ions to cross the membranes of heart cells. The task of moving charges across the lipid “hostile” environment of the cell membrane is nontrivial, and is mediated by a group of highly sophisticated, structurally complex protein molecules.
They also hypothesized that a different gate located in the cytoplasmic face of the cell membrane, the “h” gate, is responsible for terminating the influx of Na. In the model, Na influx is only possible when all three m gates and the h gate are open because the closure of either the m gates or the h gate will physically prevent ion permeation. It is easily seen how such a model may explain the existence of the three conformational states of closed, open, and inactivated. 5b, in the resting state, the channels are closed because the m gates are closed (even though the h gate is open).
Another factor to consider when designing voltage-clamp experiments is that the entire cell membrane under study must be fixed to the desired potential. If during the voltage clamp a voltage difference exists between one region of the cell (or fiber) and another, currents will flow not only across the membrane but also between the two regions that are not isopotential. 23. A long Purkinje fiber is impaled with voltage (V) and current (I) electrodes that are relatively close to each other. During a voltage-clamp step from −80 to −60 mV, the current injected by the amplifier changes the potential of the patch of membrane surrounding the voltage electrode; however, because of the length of the fiber, the membrane potential distal to the site of impalement may be different from that near the electrode.
Basic Cardiac Electrophysiology for the Clinician, Second Edition by Jose Jalife, Mario Delmar, Justus Anumonwo, Omer Berenfeld, Jerome Kalifa(auth.)