Read e-book online Cardiac Drug Development Guide PDF

By Michael K. Pugsley (auth.), Michael K. Pugsley (eds.)

ISBN-10: 1588290972

ISBN-13: 9781588290977

ISBN-10: 1592594042

ISBN-13: 9781592594047

The revolution in molecular drugs makes it significant to combine the classical and molecular methods to drug improvement for the therapy of center disorder, the number 1 killer in North the USA and Europe. within the Cardiac Drug improvement advisor, simple scientific researchers, clinicians, and pharmacologists sign up for forces to comprehensively survey the latest breakthroughs in molecular cardiology and evaluation the most recent drug discoveries in cardiac and cardiovascular medication. subject matters diversity from novel molecular goals for cardiac drug improvement, to useful endpoints for comparing cardiac drug task, to scientific features of cardiovascular therapeutics. The authors describe the main complicated approaches in cardiovascular pharmacology, together with in vivo and in vitro entire animal stories, the electrophysiological tools used to review pacemaker cells, and the applying of biochemical ideas and applied sciences to novel healing brokers. additionally mentioned are the tools used to precise the ion channels occupied with cardiovascular pharmacology, adenoviral vector supply for cardiovascular gene treatment, pharmacometrics in cardiovascular drug improvement, gender variations in center failure, and angiogenesis remedies for heart affliction. every one bankruptcy concisely illustrates the recommendations defined and comprises complete history info, targeted figures and tables, and an updated checklist of an important references.
accomplished and easy-to-understand, the Cardiac Drug improvement consultant bargains pharmacologists, cardiologists, and physiologists not just a gold-standard survey of the numerous diversified tools getting used to strengthen new center medications, but in addition information robust new ways that heart problems is focused, from the complete organ to the genetic level.

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A. (1998) H-current: Properties of a neuronal and network pacemaker. Neuron 21, 9–12. 15. Demontis, G. , and Cervetto, L. (1999) Properties and functional roles of hyperpolarization-gated currents in guinea-pig retinal rods. J. Physiol. 515, 813–828. 16. Magee, J. C. (1999) Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons. Nat. Neurosci. 2, 848. 17. Beaumont, V. and Zucker, R. S. (2000) Enhancement of synaptic transmission by cyclic AMP modulation of presynaptic Ih channels.

Role of Cardiac Pacemaker Currents 33 5. DISTRIBUTION OF HCN CHANNELS As a logical development of earlier studies demonstrating the presence and properties of I(f) in a variety of tissues, efforts have now been directed to studies defining the relative expression levels of the different isoforms of the HCN gene. The relative expression levels of the different isoforms varies considerably throughout the heart, consistent with the different properties of I(f) and the different intrinsic pacemaker activity of the tissues.

USA 89, 10910–10914. 22. Hille, B. ), Sinauer, Sunderland, UK, pp. 390–422. 23. Hille, B. (1977) Local anesthetics: Hydrophilic and hydrophobic pathways for the drug– receptor reaction. J. Gen. Physiol. 69, 497–515. 24. Hondeghem, L. M. and Katzung, B. G. (1977) Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim. Biophys. Acta. 472, 373–398. 25. Ragsdale, D. , McPhee, J. , and Catterall, W. A. (1996) Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltagegated Na+ channels.

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Cardiac Drug Development Guide by Michael K. Pugsley (auth.), Michael K. Pugsley (eds.)


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