Chapter 1 Microbial pollutants and Diarrhoeal ailments: creation and evaluate (pages 1–13): R. L. Guerrant
Chapter 2 law of Water and Ion circulation in gut (pages 14–33): Don W. Powell, Helen M. Berschneider, Larry D. Lawson and Holger Martenst
Chapter three position of the Mucosal Barrier in Toxin/Microbial Attachment to the Gastrointestinal Tract (pages 34–56): W. Allan Walker
Chapter four pollution which turn on Adenylate Cyclase (pages 57–73): D. Michael Gill and Marilyn Woolkalis
Chapter five pollutants which turn on Guanylate Cyclase: Heat?Stable Enterotoxins (pages 74–93): Mrinalini C. Rao
Chapter 6 STB Enterotoxin of Escherichia coli: Cyclic Nucleotide?Independent Secretion (pages 94–115): Cynthia S. Weikel and Richard L. Guerrant
Chapter 7 Mechanisms during which Cyclic Nucleotides and different Intracellular Mediators keep an eye on Secretion (pages 116–138): Hugo R. De Jonge and Suzanne M. Lohmannt
Chapter eight Secretory Hormones of Entamoeba histolytica (pages 139–154): Katherine McGowan, Victoria Guerina, Joan Wicks and Mark Donowitz
Chapter nine The Pharmacological amendment of Secretory Responses (pages 155–174): Richard J. Miller, David R. Brown, Eugene B. Chang and David D. Friel
Chapter 10 Salmonellosis: looking back and Prospect (pages 177–192): J. Stephen, T. S. Wallis, W. G. Starkey, D. C. A sweet, M. P. Osborne and S. Haddon
Chapter eleven Shigella Toxin and the Pathogenesis of Shigellosis (pages 193–214): Gerald T. Keusch, Arthur Donohue?Rolfe and Mary Jacewicz
Chapter 12 Staphylococcus aureus Delta Toxin as an Entero Toxin (pages 215–229): Frank A. Kapral
Chapter thirteen Clostridial pollution energetic in the community within the Gastrointestinal Tract (pages 230–241): Tracy Wilkins, Howard Krivan, Bradley Stiles, Robert Carman and David Lyerly
Chapter 14 Vaccine improvement for the regulate of Cholera and comparable Toxin?Induced Diarrhoeal ailments (pages 242–270): Jan Holmgren and Ann?Mari Svennerholm
Chapter 15 Chairman's Summing?Up (pages 271–274): Richard L. Guerrant
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Extra resources for Ciba Foundation Symposium 112 - Microbial Toxins and Diarrhoeal Disease
The role of Ca2+-calmodulin in the stimulation of guanylate cyclase is more complicated and controversial; there is evidence both for and against Ca2+ dependence of activation. The third area of interaction is the demonstration that cyclic nucleotides release 45Ca from intracellular stores in preloaded colonic cells (Frizzell 1977). More recently, measurements of intracellular calcium levels in isolated enterocytes with the Ca2+-sensitivedye, quin-2, have shown that cyclic AMP releases Ca2+from intracellular stores (E.
J Pediatr 100563-567 Haneberg B, Aarskog D 1975 Human fecal immunoglobulins in healthy infants and children, and in some with diseases affecting the intestinal tract or the immune system. CIin Exp Immunol 22:210-222 Heird W. Schwarz SM, Hansen IH 1984 Colostrum-induced enteric mucosal growth in beagle puppies. Pediatr Res 18:512-515 Jones GW. Freter R 1976 Adhesive properties of Vibrio cholerae: nature of the interaction with isolated rabbit brush border membranes and human erythrocytes. Infect Immun 14:240-245 Kraft SC.
Attachment and penetration of the mucosal barrier may in turn result in clinical disease manifested as infection/inflammation of the gastrointestinal tract or as disruption of 34 MUCOSAL BARRIER TO TOXINS 35 absorption/secretion (toxigenic diarrhoea). In order to combat the potential for microbial/toxin attachment and penetration across the mucosal barrier, man has created an elaborate system of immunological and non-immunological defences within the intestinal lumen or on the epithelial surface as a barrier to bacteria and their enterotoxins.
Ciba Foundation Symposium 112 - Microbial Toxins and Diarrhoeal Disease