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ISBN-10: 0444152725

ISBN-13: 9780444152725

ISBN-10: 047072031X

ISBN-13: 9780470720318

Content:
Chapter 1 Chairman's establishing feedback (pages 1–4): D. S. Parsons
Chapter 2 advent (pages 6–14): D. M. Matthews
Chapter three Amino Acid and Peptide Absorption in guy (pages 15–29): D. B. A. Silk
Chapter four Intestinal Dipeptidases and Dipeptide delivery within the Monkey and in guy (pages 37–61): A. N. Radhakrishnan
Chapter five Dipeptide delivery within the Intestinal Mucosa of constructing Rabbits (pages 61–78): A. Rubino and S. Guandalini
Chapter 6 Mechanisms of Peptide delivery (pages 79–108): D. Burston, T. C. Marrs, M. H. Sleisenger, T. Sopanen and D. M. Matthews
Chapter 7 A Brush?Border?Bound Peptidase and Amino Acid shipping (pages 109–121): Hans Wacker and Giorgio Semenza
Chapter eight at the functionality of the ??Glutamyl Cycle within the delivery of Amino Acids and Peptides (pages 123–150): Alton Meister, Suresh S. Tate and Gregory A. Thompson
Chapter nine Intestinal Mucosal Hydrolysis of Proteins and Peptides (pages 151–171): younger S. Kim
Chapter 10 Intracellular Hydrolysis of Peptides (pages 177–198): Ove Noren, Hans Sjostrom, Birte Svensson, Lars Jeppesen, Michael Staun and Lars Josefsson
Chapter eleven Intracellular Hydrolysis of Peptides (pages 199–208): Lars Josefsson, Hans Sjostrom and Ove Noren
Chapter 12 Endopeptidases within the Brush Border of the Kidney Proximal Tubule (pages 209–220): A. John Kenny
Chapter thirteen Membrane and Intracellular Hydrolysis of Peptides: Differentiation, position and Interrelations with delivery (pages 221–244): A. M. Ugolev, N. M. Timofeeva, L. F. Smirnova, P. De Laey, A. A. Gruzdkov, N. N. Iezuitova, N. M. Mityushova, G. M. Roshchina, E. G. Gurman, V. M. Gusev, V. A. Tsvetkova and G. G. Shcherbakov
Chapter 14 Intestinal Hydrolysis of Disaccharides and Peptides: comparability of Hydrolases and Perfusion stories (pages 245–264): J. B. Rhodes, C. Arvanitakis and J. Folscroft
Chapter 15 Clearance of Dipeptides from Plasma: position of Kidney and gut (pages 265–286): Siamak A. Adibi
Chapter sixteen Peptiduria within the Fanconi Syndrome (pages 287–303): A. M. Asatoor, M. D. Milne and J. M. Walshe
Chapter 17 delivery and Hydrolysis of Peptides via Microorganisms (pages 305–334): J. W. Payne
Chapter 18 Peptidases in Germinating Barley Grain: homes, Localization and attainable services (pages 334–352): T?M. Enari and J. Mikola
Chapter 19 ultimate dialogue (pages 353–372):
Chapter 20 remaining comments (pages 373–376): D. S. Parsons

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Extra resources for Ciba Foundation Symposium 50 - Peptide Transport and Hydrolysis

Sample text

26 D. B. A. SILK THE ROLE OF BRUSH BORDER PEPTIDASES IN THE HYDROLYSIS OF LUMINAL PEPTIDES One interesting aspect of the human perfusion experiments with the partial enzymic hydrolysates of whole protein (Figs. 5 and 6) was that the extent of absorption of many of the amino acid residues from the peptide solutions was the same as from the equivalent free amino acid solutions. In some respects this was an unexpected finding since the previous perfusion experiments with individual peptides had frequently shown faster absorption of peptide-bound than free amino acid residues.

N. Radhakrishnan, unpublished work). 0 mM. 0 mM revealed an additional mode of uptake of Gly-Leu with a K , of about 30 mM (Fig. 7). 5-100 mM) confirmed these findings of two saturable transport systems with K, values of 5 mM and 30 mM. At high concentrations of the dipeptide there is significant passive diffusion with Gly-Gly (Fig. S), but not with Gly-Leu. In man, perfusion studies with Gly-Gly did not show a biphasic uptake pattern, but since the concentration intervals (10, 25, 50 and 100 mM) were far apart further experiments in vivo are necessary to substantiate the in vitro findings.

Different usage by different people of terms such as ‘intracellular hydrolysis’ or ‘membrane digestion’ is beginning to cause much confusion. It would be an excellent thing if a few of us working in the field could agree on the usage of these terms. References ADIBI,S. , FOGEL, M. R. & AGRAWAL, R. M. (1974) Comparisons of free amino acid and dipeptide absorption in the jejunum of sprue patients. , LUNDH,G . & SJOVALL, J. (1957) Studies of intestinal digestion and absorption in the human. J. Clin.

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Ciba Foundation Symposium 50 - Peptide Transport and Hydrolysis


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