Chapter 1 creation: The Rational Use of Plasma Drug degrees in medical medication (pages 1–12): Louis Lasagna
Chapter 2 ideas of Pharmacokinetics (pages 13–33): Geoffrey T. Tucker
Chapter three Methodological Pitfalls: The impact of Experimental layout on effects (pages 35–49): Stephen H. Curry
Chapter four Interpretation of Drug degrees: Relevance of Plasma Protein Binding (pages 51–68): Emilio Perucca and Alan Richens
Chapter five quality controls of Drug Assays (pages 69–79): Alan Richens
Chapter 6 Lithium Concentrations and medical Responses (pages 81–98): John L. Crammer, A.C. Elithorn and R. Lennox
Chapter 7 Blood degrees of Flupenthixol in sufferers with Acute and persistent Schizophrenia (pages 99–114): Eve C. Johnstone, Rachel C. Bourne, P. Mary Cotes, T.J. Crow, I.N. Ferrier, F. Owen and J.D. Robinson
Chapter eight medical importance of tracking Plasma degrees of Psychotropic medicines (pages 115–139): Paolo Lucio Morselli and Edouard Zarifian
Chapter nine Benzodiazepines: a few features in their medical Pharmacology (pages 141–155): Richard I. Shader and David J. Greenblatt
Chapter 10 Adrenergic and Serotonergic Mechanisms in melancholy and Their reaction to Amitriptyline (pages 157–166): Alec Coppen and Keith Wood
Chapter eleven The position of Plasma point tracking of Tricyclic Antidepressant medicinal drugs as an reduction to remedy (pages 167–197): Robin Braithwaite
Chapter 12 medical software of the tracking of Anticonvulsant Drug degrees (pages 199–214): E.H. Reynolds
Chapter thirteen The Logistics of Drug tracking (pages 215–224): Roy Goulding
Chapter 14 replacement methods (pages 225–252): Malcolm Lader
Chapter 15 Concluding feedback (pages 253–255): Louis Lasagna
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Additional info for Ciba Foundation Symposium 74 - Drug Concentrations in Neuropsychiatry
Dubois: There are many of these compartmental models but we cannot normally decide which is the correct one. Tucker: Exactly. An infinite set of compartmental models can describe the same data on blood drug concentrations. Lader: I was interested in your demonstration that the metabolism of some drugs in the liver depended on blood flow and of others on actual enzyme activity. Can this be translated into chemical terms and related to the type of metabolic transformation? Tucker: In general I should say not.
The identity of the receptor fraction is usually unproved. It seems to me that there is no place in fine pharmacokinetics for such work, but it must be realized that objectives in clinical correlation pharmacokinetics studies vary, and I shall refer to this again later. It might be a useful outcome of this symposium if an agreed policy on non-specific assays emerged. Clearly, if different investigators are measuring different materials, correlation studies are bound to lead to different results, and if different investigators are unaware of what they are measuring, confusion is inevitable.
Hillis Miller Health Center, University of Florida, Gainesville, Florida 32610, USA. H. CURRY PROBLEMS IN CHEMICAL ANALYSIS High quality chemical analysis preceded high quality clinical evaluation. However, controversies and errors in relation to assays are still found. The basic requirement in any analytical method is usually specific measurement of one known compound with reasonable precision and accuracy. I say usually, because there is a case for non-specific measurement in certain restricted situations, and this will be considered later.
Ciba Foundation Symposium 74 - Drug Concentrations in Neuropsychiatry