New PDF release: Molecular Mechanisms of Tumor Cell Resistance to

By Khyati Kapoor, Hong May Sim (auth.), Benjamin Bonavida (eds.)

ISBN-10: 1461470692

ISBN-13: 9781461470694

ISBN-10: 1461470706

ISBN-13: 9781461470700

​​​​​This quantity offers the most recent advancements in at the mechanisms of melanoma mobile resistance to apoptotic stimuli, which ultimately lead to melanoma development and metastasis. one of many major demanding situations in melanoma study is to boost new remedies to wrestle resistant tumors. the advance of latest powerful treatments can be depending on delineating the biochemical, molecular, and genetic mechanisms that keep watch over tumor mobile resistance to cytotoxic drug-induced apoptosis. those mechanisms should still demonstrate gene items that at once control resistance in an effort to increase new medicinal drugs that concentrate on those resistance components and such new medicines may possibly both be selective or universal to varied cancers. If profitable, new medications is probably not poisonous and will be used successfully together with subtoxic traditional medicines to accomplish synergy and to opposite tumor phone resistance. The study advancements provided during this booklet may be translated to supply higher scientific responses to resistant tumors.

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Read e-book online Molecular Mechanisms of Tumor Cell Resistance to PDF

​​​​​This quantity provides the most recent advancements in at the mechanisms of melanoma cellphone resistance to apoptotic stimuli, which finally lead to melanoma development and metastasis. one of many major demanding situations in melanoma learn is to enhance new remedies to strive against resistant tumors. the advance of latest potent cures may be depending on delineating the biochemical, molecular, and genetic mechanisms that keep an eye on tumor mobile resistance to cytotoxic drug-induced apoptosis.

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Extra resources for Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy: Targeted Therapies to Reverse Resistance

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79. Basseville A, Tamaki A, Ierano C, Trostel S, Ward Y, Robey RW, Hegde RS, Bates SE. Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter. Cancer Res. 2012;72:3642–51. 80. Woodward OM, Kottgen A, Coresh J, Boerwinkle E, Guggino WB, Kottgen M. Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. Proc Natl Acad Sci USA. 2009;106:10338–42.

2011;8:1996–2011. 19. Vulevic B, Chen ZJ, Boyd JT, Davis W, Walsh ES, Belinsky MG, Tew KD. Cloning and characterization of human adenosine 50 -triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2). Cancer Res. 2001;61:3339–47. 20. Chapuy B, Koch R, Radunski U, Corsham S, Cheong N, Inagaki N, Ban N, Wenzel D, Reinhardt D, Zapf A, Schweyer S, Kosari F, Klapper W, Truemper L, Wulf GG. Intracellular ABC transporter A3 confers multidrug resistance in leukemia cells by lysosomal drug sequestration.

Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein—the two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes. J Biol Chem. 2001;276:11653–61. 115. Sauna ZE, Ambudkar SV. Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein. Proc Natl Acad Sci USA. 2000;97:2515–20. 116. Ford JM, Hait WN. Pharmacology of drugs that alter multidrug resistance in cancer.

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Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy: Targeted Therapies to Reverse Resistance by Khyati Kapoor, Hong May Sim (auth.), Benjamin Bonavida (eds.)


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